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KMID : 0360220090500050794
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Journal of the Korean Ophthalmological Society
2009 Volume.50 No. 5 p.794 ~ p.799
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Two Cases of Acute Retinal Necrosis Treated With Systemic Antiviral Drugs and Intravitreal Antiviral Injections
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Yang Ji-Wook
Kim Wung-Jae
Park Young-Hoon
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Abstract
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Purpose: To report the use of intravitreal antiviral injections as adjunctive therapy in the managementof two immunocompetent patients with acute retinal necrosis.
Case Summary: We performed two or three intravitreal injections of gancyclovir (2,000 μg/0.05 ml) on two patients (two eyes) with acute retinal necrosis resistant to intravenous acyclovir therapy (1,500 mg/m2/day). Both patients received intravitreal antiviral injections for the treatment of retinitis that progressed despite standard intravenous acyclovir therapy. The retinitis resolved, and visual acuity improved after 18 months of follow-up in both cases.
Conclusions: Intravitreal antiviral injections may be a safe and efficacious adjunctive therapy in the management of patients with acute retinal necrosis resistant to intravenous acyclovir therapy.
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KEYWORD
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Acute retinal necrosis, Gancyclovir, Intravitreal injection
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